La ciencia avanza contra la artrosis

AsideSalud
By origami
1953

Doctor Notch (Jekyll) y Mister Hyde

Este artículo que apareció en enero del 2016, me parece valioso para dárselos a conocer, por las implicaciones de una proteína muy específica, que parece relacionada en la aparición de la OA. Espero les agrade, pues la analogía del Dr. Jekyll y el señor Hyde, me parece extraordinaria.

Cuanto más se investiga sobre la artrosis, más se descubre que no es sólo un desgaste mecánico de articulaciones castigadas por años de sobreesfuerzos. Más bien, es una enfermedad compleja en la que se pierde el sutil equilibrio entre las moléculas que preservan la articulación y las moléculas que la degradan. Una larga guerra microscópica, en la que acaban ganando los malos.

En esta guerra juega un papel crucial una proteína llamada Notch, según han descubierto investigadores de EU que han presentado sus resultados en la revista Science Signaling. El estudio aclara cómo progresa la artrosis a nivel celular y abre la vía a desarrollar nuevos fármacos en el futuro para frenarla.

Conozcan a Notch

Nocht es una de las moléculas más importantes en el desarrollo del cuerpo humano. Sin ella no hubiéramos llegado a nacer. Controla el crecimiento de órganos y tejidos vitales como el cerebro, el corazón o el esqueleto. También es quien decide, en la etapa prenatal, que el corazón se sitúe a la izquierda del tórax y el hígado quede encajado por debajo de la parrilla costal a la derecha, como quien hace una maleta procurando que entre todo lo necesario y ocupe el mínimo espacio.

Después del nacimiento, Notch sigue siendo imprescindible para preservar la salud de múltiples órganos y tejidos. En el cerebro, por ejemplo, un déficit de Notch afecta al funcionamiento de las neuronas hasta el punto de causar problemas de aprendizaje y de memoria. En las articulaciones, la falta de Notch deteriora los cartílagos. Pero, paradójicamente, en las articulaciones con artrosis no se observa una falta de Notch sino un exceso. ¿Cómo explicarlo?

Dos caras de una misma molécula

En busca de respuestas, investigadores de la Universidad de Rochester en EU, liderados por Matthehw Hilton, han estudiado minuciosamente los efectos de Notch en los cartílagos. Han experimentado con cultivos celulares y con ratones de laboratorio, algunos de los cuales tenían las articulaciones sanas y otros tenían artrosis.

Según los resultados presentados en Science Signaling, cuando Notch actúa de manera intermitente y con moderación, estimula la formación de cartílago sano: el número de células (o condrocitos) aumenta y el cartílago adquiere un grosor adecuado. Pero cuando Notch está desencadenado y actúa sin freno, de manera permanente, el efecto es el contrario: el cartílago se degenera, la articulación se inflama, el menisco se estropea y el número de condrocitos se reduce.

Notch aparece así como un Doctor Jekyll y Mister Hyde de la artrosis. Una molécula que en origen es buena pero que, cuando se descontrola, se convierte en un monstruo.

¿Qué ocurriría si, en una articulación que ya tiene artrosis, se consigue controlar Notch para que vuelva a actuar con moderación?, se han preguntado los investigadores. ¿Será capaz de estimular de nuevo la formación de cartílago sano? Respuesta: cuando se reduce la actividad de Notch, el deterioro de la articulación se frena, pero el cartílago no se regenera.

En busca de nuevos fármacos

Hasta aquí, se trata de una investigación de ciencia básica que ayuda a comprender cómo se origina y progresa la artrosis, pero que de poco sirve a las personas afectadas. Sin embargo, el objetivo del equipo de la Universidad de Rochester es desarrollar fármacos que sean útiles para los pacientes. Por ello, ha estudiado cómo actúa exactamente Notch en las articulaciones con la idea de imitar sus efectos beneficiosos o de bloquear sus efectos perjudiciales. La Biociencia, la Biotecnología, la Bioingeniería, tendrán que trabajar muy duro todavía.

Sin embargo, después de tantos años en que el principal tratamiento contra la artrosis ha sido la resignación, porque se veía como un achaque de la edad contra el que poco se podía hacer, la investigación sobre Notch es un avance significativo que muestra el camino para mejorar los tratamientos y llegar a curar la enfermedad en el futuro. Un camino que pasa por comprender cuáles son las moléculas beneficiosas que protegen la articulación para ayudarlas, y cuáles son las perjudiciales para frenarlas. Y tratar de convencer a Mister Hyde para que vuelva a ser el Doctor Jekyll.

origami

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